Bresler D E, Ellison G, Zamenhof S
Dev Psychobiol. 1975 Jul;8(4):315-23. doi: 10.1002/dev.420080405.
Female rats (F0) were maintained on a protein-restricted or a normal diet 1 month prior to mating and throughout pregnancy. Their female offspring (F1) were maintained on a normal protein diet and mated with normal males. In previously reported studies, the 2nd generation offspring (F2) of the malnourished rats have been found at birth to have significantly lower cerebral DNA ( a measure of cell number), cerebral weight, and cerebral protein than normal controls. We now report that these F2 animals show marked learining deficits at maturity on 2 different successive reversal tasks, even though they themselves have never directly experienced malnutrition. Thus, certain behavioral as well as biochemical effects of malnutrition appear to the next generation of animals.
雌性大鼠（F0）在交配前1个月及整个孕期维持蛋白质限制饮食或正常饮食。它们的雌性后代（F1）维持正常蛋白质饮食，并与正常雄性大鼠交配。在先前报道的研究中，发现营养不良大鼠的第二代后代（F2）出生时大脑DNA（细胞数量的一种度量）、脑重和脑蛋白含量均显著低于正常对照组。我们现在报告，这些F2动物在成熟时在两项不同的连续反转任务中表现出明显的学习缺陷，尽管它们自身从未直接经历过营养不良。因此，营养不良的某些行为和生化影响似乎会传递给下一代动物。
