• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新生大脑中的DNA（细胞数量）：母体（F0）饮食蛋白质限制导致的第二代（F2）改变。

DNA (cell number) in neonatal brain: second generation (F2) alteration by maternal (F0) dietary protein restriction.

作者信息

Zamenhof S, van Marthens E, Grauel L

出版信息

Science. 1971 May 21;172(3985):850-1. doi: 10.1126/science.172.3985.850.

DOI:10.1126/science.172.3985.850
PMID:5572908
Abstract

Female rats were maintained on a protein-restricted diet 1 month prior to mating and throughout pregnancy. Their female offspring were maintained on a normal diet from birth or from weaning and were mated with normal males. The second generation offspring at birth still had significantly lower cerebral weight and total cerebral DNA (cerebral cell number).

摘要

雌性大鼠在交配前1个月及整个孕期维持蛋白质限制饮食。它们的雌性后代从出生或断奶后开始维持正常饮食，并与正常雄性大鼠交配。第二代后代出生时脑重量和脑总DNA（脑细胞数量）仍显著较低。

相似文献

1
DNA (cell number) in neonatal brain: second generation (F2) alteration by maternal (F0) dietary protein restriction.新生大脑中的DNA（细胞数量）：母体（F0）饮食蛋白质限制导致的第二代（F2）改变。
Science. 1971 May 21;172(3985):850-1. doi: 10.1126/science.172.3985.850.
2
Learning deficits in rats with malnourished grandmothers.祖母营养不良的大鼠存在学习缺陷。
Dev Psychobiol. 1975 Jul;8(4):315-23. doi: 10.1002/dev.420080405.
3
DNA (cell number) and protein in rat brain. Second generation (F 2 ) alteration by maternal (F 0 ) dietary protein restriction.大鼠脑中的DNA（细胞数量）和蛋白质。母代（F0）饮食蛋白质限制导致的第二代（F2）变化。
Nutr Metab. 1972;14(5):262-70. doi: 10.1159/000175390.
4
DNA (cell number) and protein in neonatal brain: alteration by maternal dietary protein restriction.
Science. 1968 Apr 19;160(3825):322-3. doi: 10.1126/science.160.3825.322.
5
DNA (cell number) and protein in neonatal rat brain: alteration by timing of maternal dietary protein restriction.
J Nutr. 1971 Sep;101(9):1265-9. doi: 10.1093/jn/101.9.1265.
6
Differential responses to prenatal malnutrition among neonatal rats.新生大鼠对产前营养不良的不同反应。
Biol Neonate. 1977;32(3-4):205-10. doi: 10.1159/000241018.
7
Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation.孕期和哺乳期喂食低蛋白饮食的大鼠雌性后代（F1）的子代（F2）生长和代谢的跨代改变中的性别差异。
J Physiol. 2005 Jul 1;566(Pt 1):225-36. doi: 10.1113/jphysiol.2005.086462. Epub 2005 Apr 28.
8
The effects of prenatal protein restriction on the developing mouse cerebrum.产前蛋白质限制对发育中小鼠大脑的影响。
J Nutr. 1978 Mar;108(3):368-72. doi: 10.1093/jn/108.3.368.
9
Protein restriction inhibits gastric cell proliferation during rat postnatal growth in parallel to ghrelin changes.蛋白质限制与生长激素释放肽变化平行抑制大鼠出生后胃细胞增殖。
Nutrition. 2012 Jun;28(6):707-12. doi: 10.1016/j.nut.2011.10.003. Epub 2011 Dec 30.
10
Oxygen consumption by brain mitochondria of rats malnourished in utero.子宫内营养不良大鼠脑线粒体的氧消耗
J Nutr. 1973 Feb;103(2):314-7. doi: 10.1093/jn/103.2.314.

引用本文的文献

1
Curcumin Induces Transgenerational and Sex-Specific Effects on Lifespan, Gene Expression, and Metabolism in the Fruit Fly Drosophila melanogaster.姜黄素对黑腹果蝇的寿命、基因表达和代谢产生跨代及性别特异性影响。
Biofactors. 2025 Jul-Aug;51(4):e70039. doi: 10.1002/biof.70039.
2
Dysregulated miR-124 mediates impaired social memory behavior caused by paternal early social isolation.miR-124 的失调介导了父代早期社会隔离引起的社会记忆行为损伤。
Transl Psychiatry. 2024 Sep 28;14(1):392. doi: 10.1038/s41398-024-03109-1.
3
Dying of pestilence: Stature and mortality from the Black Death in 14th-century Kyrgyzstan.
死于瘟疫：14 世纪吉尔吉斯斯坦黑死病的身高与死亡率。
Am J Biol Anthropol. 2024 Nov;185(3):e25009. doi: 10.1002/ajpa.25009. Epub 2024 Sep 5.
4
The postnatal window is critical for the development of sex-specific metabolic and gut microbiota outcomes in offspring.产后窗口期对于后代中性别特异性代谢和肠道微生物群结果的发展至关重要。
Gut Microbes. 2021 Jan-Dec;13(1):2004070. doi: 10.1080/19490976.2021.2004070.
5
The Impact of Diet on the Involvement of Non-Coding RNAs, Extracellular Vesicles, and Gut Microbiome-Virome in Colorectal Cancer Initiation and Progression.饮食对非编码RNA、细胞外囊泡以及肠道微生物群-病毒组在结直肠癌发生和进展中的作用的影响
Front Oncol. 2020 Dec 14;10:583372. doi: 10.3389/fonc.2020.583372. eCollection 2020.
6
Birth weight, intrauterine growth retardation and fetal susceptibility to porcine reproductive and respiratory syndrome virus.出生体重、宫内生长迟缓与胎儿对猪繁殖与呼吸综合征病毒的易感性
PLoS One. 2014 Oct 2;9(10):e109541. doi: 10.1371/journal.pone.0109541. eCollection 2014.
7
The fetal cerebral circulation: three decades of exploration by the LLU Center for Perinatal Biology.胎儿脑循环：洛马林达大学围产期生物学中心三十年的探索
Adv Exp Med Biol. 2014;814:177-91. doi: 10.1007/978-1-4939-1031-1_16.
8
The secret language of destiny: stress imprinting and transgenerational origins of disease.命运的隐秘语言：压力印记与疾病的跨代起源
Front Genet. 2012 Jun 4;3:96. doi: 10.3389/fgene.2012.00096. eCollection 2012.
9
Dietary protein restriction during F0 pregnancy in rats induces transgenerational changes in the hepatic transcriptome in female offspring.在 F0 孕期限制大鼠饮食中的蛋白质会导致雌性后代肝转录组的跨代变化。
PLoS One. 2011;6(7):e21668. doi: 10.1371/journal.pone.0021668. Epub 2011 Jul 7.
10
Growth of functional cranial components in rats submitted to intergenerational undernutrition.遭受代际营养不良的大鼠功能性颅骨成分的生长情况
J Anat. 2006 Aug;209(2):137-47. doi: 10.1111/j.1469-7580.2006.00603.x.