Basu T K, Dickerson J W, Parke D V
Nutr Metab. 1975;18(5-6):302-9. doi: 10.1159/000175608.
The effect of dietary substitution of starch by sucrose, glucose, fructose or an equimolar mixture of glucose and fructose on the activity of biphenyl hydroxylase and the level of the major terminal mixed function oxygenase, cytochrome P-450, has been studied in hepatic microsomal preparations from growing rats. The substitution of sucrose for starch depressed the contration and total activity per liver of biphenyl 4-hydroxylase and the concentration, but not the total amount, of cytochrome P-450 in weanling rats. The absolute amount of these enzymes in whole liver was not, however, similarly depressed by the constituents of sucrose, namely glucose and fructose, either when given alone or in equimolar mixture. All these sugars, however, depressed the total activity of biphenyl 2-hydroxylase. The activity of biphenyl 4-hydroxylase in the liver of weanling rats, but not of adults, was reduced when the level of sucrose in the diet was reduced from 60 to 10%.
在生长大鼠的肝微粒体制剂中，研究了用蔗糖、葡萄糖、果糖或葡萄糖与果糖的等摩尔混合物替代淀粉饮食对联苯羟化酶活性以及主要末端混合功能氧化酶细胞色素P-450水平的影响。用蔗糖替代淀粉降低了断奶大鼠中联苯4-羟化酶的浓度和每肝脏的总活性，以及细胞色素P-450的浓度，但不影响其总量。然而，蔗糖的成分葡萄糖和果糖单独或等摩尔混合给予时，全肝中这些酶的绝对量并没有类似地降低。然而，所有这些糖类都降低了联苯2-羟化酶的总活性。当饮食中蔗糖水平从60%降至10%时，断奶大鼠肝脏中联苯4-羟化酶的活性降低，但成年大鼠肝脏中的该酶活性未降低。
