Tkacheva G A, Petrova G A, Zenzerov V S, Iakovlev V A
Probl Endokrinol (Mosk). 1975 Jul-Aug;21(4):66-9.
Experiments were conducted on male Wistar rats. Incorporation into the kidney, the liver and the thyroid gland of I131-TSH and its elimination from the blood was studied. The rate of I131-TSH elimination from the blood plasma varied depending on the level of the endogenous TSH in the circulating blood of the recipient rats. The half-elimination period of the I131-TSH from the blood plasma of the intact rats constituted 10.4 minutes. In these animals the labeled hormone accumulated in the thyroid gland only 30 minutes after its administration. In case of an increase of the blood level of endogenous TSH following thyroidectomy the period of half-elimination of the I131-TSH from the plasma fell to 3.6 minutes; with reduction of the endogenous hormone level due to the block of the hypophysial secretion by triiodothyronine the period of the I131-TSH half-elimination rose to 39.4 minutes. In the latter case the labeled hormone failed to be incorporated into the thyroid gland. A conclusion was drawn on a possibility of assessing the level of the thyrotropic activity of the hypophysis on the basis of the changes in the period of the I131-TSH half-elimination from the blood plasma of the recipient animals.
实验选用雄性Wistar大鼠进行。研究了I131 - TSH在肾脏、肝脏和甲状腺中的摄取情况及其从血液中的消除情况。I131 - TSH从血浆中消除的速率因受体大鼠循环血液中内源性TSH的水平而异。完整大鼠血浆中I131 - TSH的半衰期为10.4分钟。在这些动物中，标记激素在给药后仅30分钟就积聚在甲状腺中。甲状腺切除术后内源性TSH血水平升高时，I131 - TSH从血浆中的半衰期降至3.6分钟；由于三碘甲状腺原氨酸阻断垂体分泌导致内源性激素水平降低时，I131 - TSH的半衰期升至39.4分钟。在后一种情况下，标记激素未能被甲状腺摄取。根据受体动物血浆中I131 - TSH半衰期的变化情况，得出了评估垂体促甲状腺活性水平的可能性的结论。
