Oomura Y, Nakamura T, Manchanda S K
Pharmacol Biochem Behav. 1975;3(1 Suppl):23-36.
Stimulation of the rat globus pallidus (GP) and substantia nigra (SN), while recording in the lateral hypothalamus, revealed mutual interconnections. Stimulation of GP produced an EPSP-IPSP sequence, while SN stimulation produced EPSP only. Antidromic LH spikes were obtained with either stimulation. Inhibitory interneurons responsible for the IPSP are located in the dorsolateral part of the LH. In the LH, only glucose sensitive neurons were specifically facilitated by SN stimulation and inhibited by GP stimulation. Dopamine and noradrenaline, applied electrophoretically to these neurons, yielded inhibition in a dose response manner, denying the possibility of dopamine as an excitatory transmitter substance. The mutual interrelationship between the LH and other centers, including the frontal cortex, may well influence motivation of feeding and other behavior.
在大鼠外侧下丘脑进行记录的同时，刺激苍白球（GP）和黑质（SN），发现它们之间存在相互联系。刺激GP产生一个兴奋性突触后电位-抑制性突触后电位序列，而刺激SN仅产生兴奋性突触后电位。两种刺激均可获得逆向性的下丘脑外侧峰电位。负责产生抑制性突触后电位的抑制性中间神经元位于下丘脑外侧的背侧部分。在下丘脑外侧，只有对葡萄糖敏感的神经元受到SN刺激的特异性易化，并受到GP刺激的抑制。通过电泳法将多巴胺和去甲肾上腺素施加于这些神经元，可产生剂量反应性抑制，排除了多巴胺作为兴奋性递质的可能性。下丘脑外侧与包括额叶皮质在内的其他中枢之间的相互关系很可能会影响进食动机和其他行为。
