Schrader J, Haddy F J, Gerlach E
Recent Adv Stud Cardiac Struct Metab. 1975;7:171-5.
The radioisotope method applied in the studies presented appears to be of particular advantage for the sensitive measurement of changes in adenosine release from the myocardium. The data obtained provide evidence that conditions which alter the oxygen supply to the heart such as lowering the perfusion pressure, temporary interruption of coronary inflow, and reducing oxygen content in the perfusion medium are accompanied by an enhanced release of adenosine. These results further support the concept that adenosine is a mediator in the regulation of coronary flow.
本文所呈现研究中应用的放射性同位素方法，对于灵敏测量心肌中腺苷释放的变化而言，似乎具有特别的优势。所获得的数据表明，诸如降低灌注压力、暂时中断冠状动脉血流以及降低灌注介质中的氧含量等改变心脏氧供应的情况，都伴随着腺苷释放的增加。这些结果进一步支持了腺苷是冠状动脉血流调节中的一种介质这一概念。
