Shanmugam J, Raveendranath M, Nair V R
J Indian Assoc Commun Dis. 1982 Sep-Dec;5(3-4):58-63.
Prevalence of rubella antibody in 536 and cytomegalovirus (CMV) antibody in 260 pregnant women attending an antenatal clinic, in India, was studied by means of hemagglutination inhibition (HAI) test (for rubella antibody) and complement fixation test (CFT-for CMV antibody). The antibody detection rate in pregnant women was 74.1% for rubella and 85.4% for CMV. The prevalence rate of CMV infection was higher during third trimester (89.6%), while rubella antibody was more prevalent during second trimester (77.5%). The geometrical mean titre (GMT) was 73 for rubella antibody and 57 for CMV. Further, rubella antibody was found to be more prevalent in the age group of 26-30 years (76.8%), while for CMV, the highest prevalence rate was seen in 21-25 years (89.2%). The present study indicates the potential possibility of primary rubella infection in 26.0% and CMV infection in 15.0% of the susceptible women during pregnancy and the development of congenital malformations in children born to the infected women.
在印度，通过血凝抑制试验（用于检测风疹抗体）和补体结合试验（用于检测巨细胞病毒（CMV）抗体），对一家产前诊所的536名孕妇的风疹抗体和260名孕妇的巨细胞病毒抗体的流行情况进行了研究。孕妇中风疹抗体检测率为74.1%，巨细胞病毒抗体检测率为85.4%。巨细胞病毒感染的流行率在妊娠晚期较高（89.6%），而风疹抗体在妊娠中期更为普遍（77.5%）。风疹抗体的几何平均滴度（GMT）为73，巨细胞病毒为57。此外，风疹抗体在26 - 30岁年龄组中更为普遍（76.8%），而对于巨细胞病毒，在21 - 25岁年龄组中流行率最高（89.2%）。本研究表明，在妊娠期，26.0%的易感女性有原发性风疹感染的潜在可能性，15.0%的易感女性有巨细胞病毒感染的潜在可能性，且感染女性所生儿童有发生先天性畸形的风险。
