Canessa A, Pantarotto F, Miletich F, Russo A, Gotta C, Bozzuffi P M, Ferrari G, Fiorelli A, Terragna A
1st Clinic for Infectious Diseases, University of Genoa, Italy.
Biol Res Pregnancy Perinatol. 1987;8(2 2D Half):84-8.
A study on the prevalence of seropositivity to T.gondii, Rubella virus, Cytomegalovirus and Herpes simplex virus (type 1 and type 2) was carried out in pregnant women aged 15-45 years. An overall prevalence of 40.7% to T.gondii, of 90.1% to Rubella virus, of 80.8% to Cytomegalovirus, of 82.3% and of 69% to Herpes simplex virus, respectively type 1 and type 2 was found. Cytomegalovirus infection was prevalent in women from low socioeconomic background. Herpes simplex 1 infection was higher in women living in quarters of high density population, whereas antibody prevalence to Rubella virus was higher in women from high socioeconomic setting. The expected fetal risk for T.gondii, Rubella and Cytomegalovirus infections has been assessed on the basis of the yearly seroconversion rate for each pathogen in the study population and of the known transplacental transmission rates after primary and recurrent infection in pregnancy. Thus, the expected incidence of congenital T.gondii infection in this geographic area is 0.2-0.3%, of congenital Rubella infection of 0.02% and of congenital Cytomegalovirus infection of 0.3-1.15%.
对15至45岁的孕妇进行了一项关于弓形虫、风疹病毒、巨细胞病毒和单纯疱疹病毒（1型和2型）血清阳性率的研究。结果发现，弓形虫的总体血清阳性率为40.7%，风疹病毒为90.1%，巨细胞病毒为80.8%，单纯疱疹病毒1型和2型分别为82.3%和69%。巨细胞病毒感染在社会经济背景较低的女性中较为普遍。单纯疱疹病毒1型感染在高密度人群居住的女性中较高，而风疹病毒抗体阳性率在社会经济背景较高的女性中较高。根据研究人群中每种病原体的年血清转化率以及孕期初次和复发感染后的已知经胎盘传播率，评估了弓形虫、风疹和巨细胞病毒感染对胎儿的预期风险。因此，该地理区域先天性弓形虫感染的预期发病率为0.2 - 0.3%，先天性风疹感染为0.02%，先天性巨细胞病毒感染为0.3 - 1.15%。
