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在改良的“柯克肺模型”中,对吸入气溶胶颗粒的沉积随空气流速的变化情况进行的一项研究。

An investigation into the deposition of inhalation aerosol particles as a function of air flow rate in a modified 'Kirk Lung'.

作者信息

Davies P J, Hanlon G W, Molyneux A J

出版信息

J Pharm Pharmacol. 1976 Dec;28(12):908-11. doi: 10.1111/j.2042-7158.1976.tb04089.x.

Abstract

The effect of air flow rate on the deposition of inhalation aerosol particles in a modified 'Kirk Lung' has been studied. Two commercial products were used. The amount depositied in the mouthpiece and throat regions decreases with increasing flow rate. The amount in the collector rises to maximum of approximately 50%. This material represents the therapeutically available portion. Such an apparatus would be useful for routine quality control of the size distribution ratios for inhalation aerosol particles.

摘要

研究了气流速率对改良型“柯克肺”中吸入气溶胶颗粒沉积的影响。使用了两种商业产品。随着流速增加,沉积在吸嘴和喉部区域的量减少。收集器中的量上升至约50%的最大值。该物质代表治疗可用部分。这样的装置对于吸入气溶胶颗粒尺寸分布比的常规质量控制将是有用的。

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