Plenk H
Wien Klin Wochenschr. 1975 Nov 14;87(21):719-22.
In the lumbar vertebrae of lathyritic rats bone remodelling was investigated using histomorphometrical and tetracycline labelling methods and a newly developed, computer-aided photometrical quantitation of mineral densities in microradiographs. The morphometrical analysis showed a high-graded decrease in cancellous bone due to increased resorption and cessation of endochondral bone formation. On the other hand, increased formation of new bone in sites of muscular insertion led to the formation of exostoses. Disturbed mineralisation of the newly-formed bone is indicated by increased osteoid volume and diffuse labelling with tetracycline. These findings were confirmed by the quantitation of the mineral densities. The mineralisation defect is related to the disturbed collagen synthesis in lathyrism.
使用组织形态计量学和四环素标记方法以及一种新开发的计算机辅助光度法定量微放射照片中的矿物质密度，对患有山黧豆中毒的大鼠腰椎骨重塑进行了研究。形态计量学分析表明，由于吸收增加和软骨内成骨停止，松质骨高度减少。另一方面，肌肉附着部位新骨形成增加导致骨赘形成。类骨质体积增加和四环素弥漫性标记表明新形成骨的矿化受到干扰。这些发现通过矿物质密度定量得到证实。矿化缺陷与山黧豆中毒中胶原蛋白合成紊乱有关。
