Bhattacharya Kirsty, Velickovic Miodrag, Schilsky Michael, Kaufmann Horacio
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Clin Auton Res. 2002 Jun;12(3):190-2. doi: 10.1007/s10286-002-0017-y.
We studied autonomic cardiovascular function in fourteen patients with Wilson's disease. Four had abnormalities on autonomic testing and, of these, three had evidence of severe central nervous system abnormalities. In contrast, of the remaining ten patients with normal cardiovascular reflexes, only two had severe deficits of the central nervous system. We suggest that autonomic impairment in Wilson's disease is due to involvement of central autonomic neurons.
我们研究了14例威尔逊氏病患者的自主心血管功能。4例自主神经测试异常，其中3例有严重中枢神经系统异常的证据。相比之下，其余10例心血管反射正常的患者中，只有2例有严重的中枢神经系统缺陷。我们认为威尔逊氏病中的自主神经损伤是由于中枢自主神经元受累所致。
