An advanced approach for the assessment of gastric motor function in long-term type 1 diabetes mellitus with and without autonomic neuropathy.

Gastric motor dysfunction is a frequent and deleterious long-term complication in diabetes mellitus (DM) but the exact contribution of diabetic autonomic dysfunction remains unclear. The aim of this study was to assess indices of gastric motor function in long-term Type 1 DM in the light of the presence and absence of autonomic neuropathy by means of an advanced dynamic scintigraphic technique. Gastric scintigraphy with condensed images of a short dynamic sequence was applied to 27 long-term Type 1 diabetic patients (duration > 10 years) and 15 control subjects. Two indices of gastric peristalsis, the frequency of contractions (FC) and amplitude of contractions (AC), were assessed scintigraphically together with half-time of gastric emptying (t 1/2). Five cardiac reflex tests were performed to study electrocardiogram (ECG)-based cardiac autonomic neuropathy (CAN). Mean AC was significantly decreased in diabetic patients compared to control subjects (13 +/- 9% vs. 28 +/- 8%, p < 0.005). Mean FC was comparable between diabetic patients and control subjects min(-1). (3.1 +/- 0.4 min(-1) vs. 3.1 +/- 0.2 Compared to control subjects, half-time of gastric emptying was significantly prolonged in diabetic patients (31 +/- 17 min vs. 20 +/- 3 min, p < 0.001). Mean AC, FC and t 1/2 did not differ significantly between diabetic patients with (n = 10) and without (n = 17) ECG-based CAN. Our study demonstrates that in both long-term Type 1 DM with and without autonomic neuropathy, the amplitude but not the frequency of gastric contractions, is frequently reduced. A delay of gastric emptying in Type 1 DM is confirmed although it was independent from the presence of cardiac autonomic neuropathy (CAN). Analyzing gastric motor function with dynamic scintigraphic techniques using condensed images is a promising clinical approach to further elucidate the mechanisms of impaired gastric motility in DM.