蠕动幅度和频率对胃排空和混合的影响：模拟研究。
Effects of peristaltic amplitude and frequency on gastric emptying and mixing: a simulation study.
机构信息
Graduate School of Engineering, Kobe University, Kobe, Japan.
Graduate School of Science and Technology, Hirosaki University, Hirosaki, Japan.
出版信息
J R Soc Interface. 2023 Jan;20(198):20220780. doi: 10.1098/rsif.2022.0780. Epub 2023 Jan 4.
The amplitude and frequency of peristaltic contractions are two major parameters for assessing gastric motility. However, it is not fully understood how these parameters affect the important functions of the stomach, such as gastric mixing and emptying. This study aimed to quantify the effects of peristaltic amplitude and frequency on gastric mixing and emptying using computational fluid dynamics simulation of gastric flow with an anatomically realistic model of the stomach. Our results suggest that both the increase and decrease in peristaltic amplitude have a significant impact on mixing strength and emptying rate. For example, when the peristaltic amplitude was 1.2 times higher than normal, the emptying rate was 2.7 times faster, whereas when the amplitude was half, the emptying rate was 4.2 times slower. Moreover, the emptying rate increased more than proportionally with the peristaltic frequency. The nearest contraction wave to the pylorus and the subsequent waves promoted gastric emptying. These results suggest the importance of maintaining parameters within normal ranges to achieve healthy gastric function.
蠕动幅度和频率是评估胃动力的两个主要参数。然而，人们尚不完全了解这些参数如何影响胃的重要功能，如胃混合和排空。本研究旨在使用胃流的计算流体动力学模拟，结合胃的解剖学现实模型，量化蠕动幅度和频率对胃混合和排空的影响。我们的结果表明，蠕动幅度的增加和减少对混合强度和排空率都有显著影响。例如，当蠕动幅度比正常高 1.2 倍时，排空率快 2.7 倍，而当幅度减半时，排空率慢 4.2 倍。此外，排空率随蠕动频率的增加呈超比例增加。最接近幽门的收缩波和随后的波促进了胃排空。这些结果表明，维持参数在正常范围内对于实现健康的胃功能非常重要。
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