一名患有常见变异型免疫缺陷的儿童出现全垂体功能减退。
Panhypopituitarism in a child with common variable immunodeficiency.
作者信息
Younes Jihad S, Secord Elizabeth A
机构信息
Division of Allergy, Immunology, and Rheumatology, Children's Hospital of Michigan, Detroit 48201, USA.
出版信息
Ann Allergy Asthma Immunol. 2002 Sep;89(3):322-5. doi: 10.1016/S1081-1206(10)61963-1.
BACKGROUND
Common variable immunodeficiency (CVID) represents a group of heterogeneous, still undifferentiated, syndromes that are all characterized by defective antibody formation. It is often associated with autoimmune disease.
METHODS
An African-American girl was diagnosed with CVID at age 3 years. She was seen during an adrenal crisis precipitated by pneumonia at the age of 8 years and 10 months. The diagnosis of panhypopituitarism was established soon after.
RESULTS
Panhypopituitarism in this patient was believed to be the result of the autoimmune process known as lymphocytic hypophysitis. This hypothesis was suggested by the results of magnetic resonance imaging.
CONCLUSIONS
Awareness of the possibility of this process in children or adults with CVID may lead to earlier diagnosis of panhypopituitarism. These patients also have failure to thrive, and earlier diagnosis may avoid a life-threatening event.
背景
常见变异型免疫缺陷（CVID）是一组异质性、尚未分化的综合征，其共同特征是抗体形成缺陷。它常与自身免疫性疾病相关。
方法
一名非裔美国女孩3岁时被诊断为CVID。她在8岁10个月时因肺炎引发肾上腺危象前来就诊，随后不久确诊为全垂体功能减退症。
结果
该患者的全垂体功能减退症被认为是淋巴细胞性垂体炎这一自身免疫过程的结果。磁共振成像结果提示了这一假说。
结论
认识到CVID儿童或成人发生这一过程的可能性，可能会更早诊断出全垂体功能减退症。这些患者还存在生长发育迟缓的情况，更早诊断可避免危及生命的事件发生。
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