Kauer M, Vuskovic V, Dual J, Szekely G, Bajka M
Centre of Mechanics, ETH Zurich, 8092 Zurich, Switzerland.
Med Image Anal. 2002 Sep;6(3):275-87. doi: 10.1016/s1361-8415(02)00085-3.
In this work a tissue aspiration method for the in vivo determination of biological soft tissue material parameters is presented. An explicit axisymmetric finite element simulation of the aspiration experiment is used together with a Levenberg-Marquardt algorithm to estimate the material model parameters in an inverse parameter determination process. An optimal fit of the simulated experiment and the real experiment is sought with the parameter estimation algorithm. Soft biological tissue is modelled as a viscoelastic, non-linear, nearly incompressible, isotropic continuum. Viscoelasticity is accounted for by a quasi-linear formulation. The aspiration method is validated experimentally with a synthetic material. In vivo (intra-operatively during surgical interventions) and ex vivo experiments were performed on human uteri.
在这项工作中，提出了一种用于体内测定生物软组织材料参数的组织抽吸方法。将抽吸实验的显式轴对称有限元模拟与Levenberg-Marquardt算法一起用于在逆参数确定过程中估计材料模型参数。使用参数估计算法寻求模拟实验与实际实验的最佳拟合。软生物组织被建模为粘弹性、非线性、几乎不可压缩的各向同性连续体。粘弹性通过准线性公式来考虑。用合成材料对抽吸方法进行了实验验证。在人体子宫上进行了体内（手术干预期间术中）和体外实验。
