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猪肾力学性能评估。

Evaluation of the mechanical properties of porcine kidney.

机构信息

State Key Laboratory of Science and Technology of Explosion, Beijing Institue of Technology, Beijing, China.

Department of Hepatobiliary and Pancreatic Surgery, The First Medical Center of the PLA General Hospital, Beijing, China.

出版信息

PLoS One. 2024 Jul 25;19(7):e0307778. doi: 10.1371/journal.pone.0307778. eCollection 2024.

Abstract

With the development of medical diagnosis and treatment, knowing the mechanical properties of living tissues becomes critical. The aim of this study was to investigation material properties of the fresh porcine kidney and the parametric characterization of its viscoelastic material behavior. The material investigation included uniaxial tension tests in different strain rates, relaxation tests, as well as hydrostatic compression tests on the samples extracted from the fresh porcine kidney cortex. Tension tests and relaxation tests were performed by a planar dog-bone specimen with a micron loading testing machine. Hydrostatic compression tests were performed on the kidney cylinder sample which was placed in a compression chamber. Furthermore, a nonlinear viscoelastic model recently proposed by us was employed to characterize the tension data at different strain rates and relaxation test data. The the experimental and numerical results show that the stress-strain relations of the porcine kidney cortex at different strain rates in tension are presented for the first time and a higher strain rate results in higher ultimate strength and initial Young modulus but a lower rupture strain. A damage-dependent visco-elastic model is employed to model the tension data at different strain rates and relaxation data and exhibits a good agreement with the experimental data, which also demonstrates that the damage has an obvious influence on the stress-strain relation. Through comparison with the existing reference covering the uniaxial compression data, it seems that the mechanical behavior of the porcine kidney cortex manifests a stress state-dependent mechanical behavior. The ultimate strength and rupture strain are larger in compression than that in tension.

摘要

随着医学诊断和治疗的发展,了解活体组织的力学性能变得至关重要。本研究旨在研究新鲜猪肾的材料性能及其黏弹性材料行为的参数特征。材料研究包括在不同应变速率下进行的单轴拉伸试验、松弛试验以及从新鲜猪肾皮质中提取的样品的静水压缩试验。拉伸试验和松弛试验采用平面狗骨试件和微加载试验机进行。静水压缩试验在置于压缩室的肾圆柱样品上进行。此外,我们最近提出的一种非线性黏弹性模型用于对不同应变速率下的拉伸数据和松弛试验数据进行特征化描述。实验和数值结果表明,首次给出了不同应变速率下猪肾皮质的拉伸应力-应变关系,较高的应变速率导致较高的极限强度和初始杨氏模量,但较低的断裂应变。采用损伤相关黏弹性模型对不同应变速率下的拉伸数据和松弛数据进行建模,与实验数据吻合较好,这也表明损伤对应力-应变关系有明显影响。通过与涵盖单轴压缩数据的现有参考资料进行比较,似乎猪肾皮质的力学行为表现出与应力状态相关的力学行为。在压缩下的极限强度和断裂应变大于拉伸下的极限强度和断裂应变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77a1/11271945/f44b44cbd6e5/pone.0307778.g001.jpg

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