Zaostrovskiĭ O V, Mil'shteĭn G I
Biull Eksp Biol Med. 1975 May;79(5):59-61.
The motor activity of dogs was quantitatively recorded before and after the intramuscular injection of amizyl (2 mg/kg). Amizyl was found to induce hyperactivity for 2-3 hours. Galanthamine (3 mg/kg) blocked the effect of amizyl. Etaperazine was the most active substance of the neuroleptic tranquillizers tested. Chlorpromazine and diazepam deranged the dogs' state. Diazepam and haloperidol potentiated the effect of amizyl. Motor hyperactivity induced by amizyl is supposed to be connected with anticholinergic mechanisms; no neuroleptics with cholinolytic properties should be used for the treatment of amizyl intoxication.
在肌肉注射阿米齐尔（2毫克/千克）前后，对狗的运动活动进行了定量记录。发现阿米齐尔会诱发2至3小时的多动。加兰他敏（3毫克/千克）可阻断阿米齐尔的作用。乙哌立松是所测试的抗精神病镇静剂中活性最强的物质。氯丙嗪和地西泮扰乱了狗的状态。地西泮和氟哌啶醇增强了阿米齐尔的作用。阿米齐尔诱发的运动性多动被认为与抗胆碱能机制有关；不应使用具有胆碱溶解特性的抗精神病药物来治疗阿米齐尔中毒。
