Gromov A I
Farmakol Toksikol. 1975 Mar-Apr;38(2):145-8.
Tests conducted with mice demonstrated the neuroleptics droperidol, galoperidol and aethaperazine capable of subduing in mice greatly the agressive reaction provoked by an electric stimulation of pain and to distinctly raise at the same time the sensitivity of the M-cholinoreactive systems of the brain to the tremor-inducing effect of arecoline. Amizyl (benactyzil) and cyclodol, by abolishing this M-cholinopositive action of the neuroleptics, greatly reduce, at the same time, their antiagressive activity, Il may be presumed that in the antiagressive activity of neuroleptics the activation of the M-cholinergic plays a definite part in cerebral mechanisms produced by them.
对小鼠进行的试验表明，精神抑制药氟哌利多、加洛哌丁醇和乙哌嗪能够极大地抑制小鼠因疼痛电刺激引发的攻击反应，同时显著提高大脑中M胆碱反应系统对槟榔碱致震颤效应的敏感性。阿米齐尔（苯那替秦）和赛克洛多尔通过消除精神抑制药的这种M胆碱阳性作用，同时极大地降低了它们的抗攻击活性。可以推测，在精神抑制药的抗攻击活性中，M胆碱能的激活在它们所产生的大脑机制中起一定作用。
