[放线菌素C14在对该制剂有抗性的艾氏癌小鼠体内的分布]
[Olivomycin-C14 distribution in the body of mice with Ehrlich's carcinoma resistant to the preparation].
作者信息
Vatin A E
出版信息
Farmakol Toksikol. 1975 Mar-Apr;38(2):224-6.
PMID:1227896
Abstract
Tests on mice with Ehrlich's carcinoma (solid and ascitic forms) evidenced that following a single intravenous injection of glycomycin-C14 its maximal concentrations are definable in 30 minutes--1 hour in the kidneys, liver, spleen and the blood (plasma). Six to seven percent of the total radioactivity of the tumor cells fell to the share of the nuclear fraction, while the rest of 93-94 per cent was made up by the remaining cellular components.
摘要
对患有艾氏腹水癌（实体瘤和腹水型）的小鼠进行的实验表明，单次静脉注射糖霉素 - C14后，在30分钟至1小时内可在肾脏、肝脏、脾脏和血液（血浆）中确定其最大浓度。肿瘤细胞总放射性的6% - 7%属于细胞核部分，其余93% - 94%由其余细胞成分组成。
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