Bobikov E V, Terent'eva T G, Torbochkina L I, Sokolov A B, Sazykin Iu O
Antibiotiki. 1975 Aug;20(8):705-9.
Distribution of antitumor antibiotics, i.e. C14-variamycin and C14-mitramycin in the organs of albino mice after their intravenous administration in single doses was studied. Similarity in the distribution dynamics of both the antibiotics with respect to the animal organs was found. However, the level of variamycin as compared to that of mitramycin was much higher in the liver and especially the spleen. In the experiments with variamycin the radioactivity of the kidney tissue decreased more rapidly than in the experiments with mitramycin. Chromatographic analysis of the urine of the mice treated with C14-variamycin was performed. The labeled Variamycin was detected in the animal urine within 48 hours from the moment of the antibiotic administration. Its portion in the total amount of the radioactive products in the urine was 30 to 40% at various stages of the study.
研究了抗肿瘤抗生素，即C14 - 变霉素和C14 - 光神霉素单次静脉注射后在白化小鼠器官中的分布情况。发现这两种抗生素在动物器官中的分布动态具有相似性。然而，与光神霉素相比，变霉素在肝脏尤其是脾脏中的水平要高得多。在用变霉素进行的实验中，肾组织的放射性比用光神霉素进行的实验中下降得更快。对用C14 - 变霉素处理的小鼠尿液进行了色谱分析。在给予抗生素后48小时内，在动物尿液中检测到了标记的变霉素。在研究的各个阶段，其在尿液中放射性产物总量中的比例为30%至40%。
