Tamarkina A D, Annenkov G A, Kuliev A M, Grinberg K N
Genetika. 1975 Apr;11(4):142-5.
The activity of five enzymes (AIP, AcP, GOT, LDH, MDH) was investigated in four cell strains derived from spontaneous abortuses with C-trisomy (three cell strains with trisomy 7, one--with trisomy 9). Significant differences in the activity of three enzymes were revealed. In all the strains AIP activity was lower and GOT activity--higher than in diploid strains. Lowering of AcP level was found in three strains (two cell strains with trisomy 7, one--with trisomy 9). The data obtained are evaluated as a result of disturbed regulatory interrelations in an abnormal genome.
对源自18三体综合征自然流产胎儿的四种细胞株（三株为7三体，一株为9三体）中的五种酶（碱性磷酸酶、酸性磷酸酶、谷草转氨酶、乳酸脱氢酶、苹果酸脱氢酶）活性进行了研究。结果显示三种酶的活性存在显著差异。在所有细胞株中，碱性磷酸酶活性低于二倍体细胞株，而谷草转氨酶活性则高于二倍体细胞株。在三株细胞株（两株7三体，一株9三体）中发现酸性磷酸酶水平降低。所获数据被评估为异常基因组中调节相互关系紊乱的结果。
