Moldoveanu E, Klein R, Bartoc R, Bruhis S, Oeriu I
Mech Ageing Dev. 1975 Sep-Dec;4(5-6):423-9. doi: 10.1016/0047-6374(75)90043-3.
This paper is part of a series aimed to investigate the mechanism of the action of Folcysteine, a substance that has the capacity to release in the body active -SH groups and has been proved to be effective in the control of menopausal troubles. As an experimental model the ovariectomized rat, rather similar, from the viewpoint of the hormonal balance, to the aged female, has been considered. Under these conditions, the effect, at the uterine and adrenalian level of the treatment with two different doses of estradiol with Folcysteine alone as well as associated with estradiol, has been investigated. Our results indicate that the active -SH groups released by Folcysteine intensify the effect of estrogens upon the uterine tissue and stimulate the estrogen biosynthesis at adrenalian level.
本文是一系列研究的一部分，旨在探究半胱氨酸的作用机制。半胱氨酸是一种能够在体内释放活性巯基的物质，且已被证明对控制更年期问题有效。从激素平衡的角度来看，切除卵巢的大鼠与老年雌性大鼠颇为相似，因此被用作实验模型。在此条件下，研究了单独使用两种不同剂量的雌二醇以及将其与半胱氨酸联合使用时，在子宫和肾上腺水平的治疗效果。我们的结果表明，半胱氨酸释放的活性巯基会增强雌激素对子宫组织的作用，并刺激肾上腺水平的雌激素生物合成。
