Meglioli G
J Reprod Fertil. 1976 Mar;46(2):395-9. doi: 10.1530/jrf.0.0460395.
Ovariectomized adult rats with closed uteri were treated for 7 days with different oral and s..c. doses of oestradiol, oestrone, oestriol and ethinyl oestradiol. All treatments elicited the production of uterine fluid and the potencies of oestrogens were related to the amount of fluid secreted. Ethinyl oestradiol and oestradiol displayed similar activity when given s.c. A daily dose of 0-003 mg oestradiol/kg resulted in about 700 mg fluid. Oestrone was 3-10 times and oestriol about 100 times less active. Orally, ethinyl oestradiol was the most potent substance and 700 mg secretion was obtained with a dose of 0-03 mg/kg daily. Oestradiol was about 30 times, oestrone about 100 times and oestriol 50 times less active than ethinyl oestradiol by this route. The viscosity of the secretion was unaffected, remaining between 1-6 and 2-4 cP. The pH of the fluid did not change, but that of the uterine lumen diminished slightly. These effects of oestrogens were associated with an increase in the weight of the empty uterus and a decrease in body weight.
对子宫封闭的成年去卵巢大鼠，用不同口服和皮下剂量的雌二醇、雌酮、雌三醇和炔雌醇进行7天的治疗。所有治疗均引起子宫液的产生，雌激素的效力与分泌的液体量相关。皮下给药时，炔雌醇和雌二醇表现出相似的活性。每日剂量为0.003mg雌二醇/kg时，产生约700mg液体。雌酮的活性低3至10倍，雌三醇的活性约低100倍。口服时，炔雌醇是最有效的物质，每日剂量为0.03mg/kg时可产生700mg分泌物。通过该途径，雌二醇的活性比炔雌醇低约30倍，雌酮约低100倍，雌三醇约低50倍。分泌物的粘度未受影响，保持在1.6至2.4厘泊之间。液体的pH值没有变化，但子宫腔的pH值略有下降。雌激素的这些作用与空子宫重量增加和体重减轻有关。
