Kendysh I N
Probl Endokrinol (Mosk). 1975 Sep-Oct;21(5):68-73.
A study was made of the intensity of lipid synthesis in the liver and adipose tissue of rats following a single administration of hydrocortisone (3, 6, 24 and 48 hours) from various labeled precursors. In the liver the hormone stimulated the synthesis of lipids from the acetate-I-C14 and lactate 1,3-C14 but blocked the lipogenesis from glycerine-1,2-C14 and glucose-1-c14. In the adipose tissue hydrocortisone intensified the lipid synthesis from glucose-1-C14 only and inhibited the lipid synthesis from other precursors. The action mechanism of the hormone on the lipogenesis is considered in association with the primary intensification of gluconeogenesis in the liver.
对单次注射氢化可的松后不同标记前体在大鼠肝脏和脂肪组织中脂质合成强度进行了研究（分别在注射后3、6、24和48小时）。在肝脏中，该激素刺激从乙酸 -I-¹⁴C和乳酸1,3-¹⁴C合成脂质，但阻断从甘油-1,2-¹⁴C和葡萄糖-1-¹⁴C的脂肪生成。在脂肪组织中，氢化可的松仅增强从葡萄糖-1-¹⁴C的脂质合成，并抑制从其他前体的脂质合成。该激素对脂肪生成的作用机制与肝脏中糖异生的初步增强相关联进行了探讨。
