Sargent D R, Clifton G G, Bryant S R, Skinner C G
Tex Rep Biol Med. 1975;33(3):433-43.
Pantothenic acid analogs have been synthesized that contain alkyl and/or arylureido and carbamate functions in the beta-alanyl portion of the amide moiety of the vitamin. The analogs are inhibitory to growth of lactic acid bacteria at concentrations as low as 0.6 mug/ml, and the inhibitions are competitively reversed by supplements of pantothenic acid. The carbamate derivatives are more toxic to growth of Lactobacillus plantarum 8014 and Pediococcus cerevisiae 8042 than the ureido analogs, and chloro-substitutents on the aryl group significantly increase the toxicity of the analogs.
已合成泛酸类似物，其在维生素酰胺部分的β-丙氨酰部分含有烷基和/或芳基脲基及氨基甲酸酯官能团。这些类似物在低至0.6微克/毫升的浓度下对乳酸菌的生长具有抑制作用，且泛酸补充剂可竞争性逆转这种抑制作用。氨基甲酸酯衍生物对植物乳杆菌8014和酿酒酵母8042生长的毒性比脲基类似物更大，芳基上的氯取代基显著增加了类似物的毒性。
