Abdalla R E, El Hadi A, Ahmed M A, El Hassan A M
Trans R Soc Trop Med Hyg. 1975;69(5-6):443-9. doi: 10.1016/0035-9203(75)90095-4.
New cases of mucosal leishmaniasis and the first case of espundia-like muco-cutaneous leishmaniasis are reported from the Sudan. Cases previously reported are reviewed and the geographical distribution, clinical features, pathology, immunology and treatment of the disease are described. The majority of cases came from the known kala azar endemic regions of the central Sudan. The disease was seen in adult males, it commonly affected the mouth and nose causing in some cases permanent damage to teeth and nasal septi. In the lesions, the cellular infiltrate was composed mainly of histiocytes, lymphocytes and plasma cells. The number of parasites present was inversely related to the number of lymphocytes but was not related to the number of plasma cells. The level of the increased serum immunoglobulins was not constantly correlated with the number of any particular cell in the infiltrate. Treatment with sodium stibogluconate (Pentostam) was effective in the majority of cases.
苏丹报告了黏膜利什曼病的新病例以及首例类埃斯庞迪亚型黏膜皮肤利什曼病病例。对先前报告的病例进行了回顾，并描述了该疾病的地理分布、临床特征、病理学、免疫学及治疗情况。大多数病例来自苏丹中部已知的黑热病流行地区。该病见于成年男性，通常累及口腔和鼻腔，在某些情况下会对牙齿和鼻中隔造成永久性损害。在病变中，细胞浸润主要由组织细胞、淋巴细胞和浆细胞组成。寄生虫数量与淋巴细胞数量呈负相关，但与浆细胞数量无关。血清免疫球蛋白升高的水平与浸润中任何特定细胞的数量并无持续关联。多数病例使用葡萄糖酸锑钠（葡酸锑钠）治疗有效。
