HLA-A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP).

BACKGROUND/AIM: There is growing indication that differences in host response determine susceptibility and resistance to periodontal disease. Particularly, the effect of histocompatibility antigens (HLA) on early onset periodontitis (EOP) has been studied. As most of the results are not conclusive and to date no report has been done on German patients, the aim of this study was to investigate the distribution of HLA alleles in a group of 50 German RPP patients and 102 German AP patients and to compare them to 102 control probands without periodontitis.

METHODS

Diagnosis was established according to standardised clinical criteria. HLA typing was performed using serologic and molecular biologic (PCR-SSP) techniques.

RESULTS

Compared to the controls, RPP patients had a significantly higher frequency of HLA-DRB113 and a significantly lower frequency of HLA-DRBblank(non-DRB3/4/5). AP patients showed a significantly increased occurrence of HLA-B14 and -Cw08 as well as a significantly decreased frequency of HLA-A03. In both patient groups HLA-A11 and -A29 had an increased frequency and HLA-A31 and -A*30/31 were decreased. These differences were statistical significant in the whole patient group (RPP + AP).

CONCLUSIONS

Based on modern DNA techniques the present study shows an association of HLA to both RPP and AP. Certain HLA alleles seem to be associated with susceptibility or resistance to periodontitis in general. However, before this knowledge can be used for differential diagnosis or prognosis, further investigations are necessary.