Bernhard W F, Poirier V, LaFarge C G
J Thorac Cardiovasc Surg. 1975 Feb;69(2):223-9.
Hypoplasia of the aortic valve annulus and ascending aorta is a rare form of congenital aortic stenosis, with a poor prognosis. Replacement of the aortic valve and ascending aorta with a suitable prosthesis is feasible, but the hypoplastic valve annulus must also be enlarged if an adult-sized aortic valve is to be placed in the subcornary position. In an effort to develop a new method of surgical treatment for this congenital abnormality, we fabricated a prosthesis which can be interposed between the left ventricular apex and descending thoracic aorta. This prosthesis is coupled to a 25 mm. Dacron graft and xenograft valve and is lined with flocked Dacron fibrils to encourage formation of a stable biologic lining and prevent thrombus buildup. The prosthesis was implanted in a 22 year old male patient of the Children's Hospital Medical Center without difficulty. Postoperative cardiac catheterization idicated that all of the contrast material was ejected from the left ventricle through the prosthesis. The patient was discharged from the hospital taking sodium warfarin and remains entirely asymptomatic.
主动脉瓣环和升主动脉发育不全是一种罕见的先天性主动脉狭窄形式,预后较差。用合适的人工假体置换主动脉瓣和升主动脉是可行的,但如果要在冠状动脉下位置植入成人尺寸的主动脉瓣,发育不全的瓣膜环也必须扩大。为了开发一种针对这种先天性异常的新手术治疗方法,我们制造了一种可以置于左心室心尖和胸降主动脉之间的假体。该假体与一个25毫米的涤纶移植物和异种移植瓣膜相连,并内衬植绒涤纶纤维,以促进稳定生物内膜的形成并防止血栓形成。该假体顺利植入儿童医院医疗中心一名22岁男性患者体内。术后心导管检查表明,所有造影剂都通过假体从左心室排出。患者出院时服用华法林钠,至今完全无症状。