Gayral M N, Millet D, Netter A
J Gynecol Obstet Biol Reprod (Paris). 1975 Mar;4(2):255-66.
Hyperstimulation appeared in one case on the 10th 11th day after ovulation, allowing by its presence the very precocious diagnosis of successful fecondation. The study of blood coagulation revealed that hypercoagulability was mainly related to hyperactivity of the thrombocytes and of the coagulation proteins. The pathogenesis of the syndrome is discussed. Increase in the permeability of the capillary vessels and hypovolemia seem to be responsible for the main accidents. Unfortunately as we have no real mean of decreasing the permeability of the capillary vessels, the treatment can be directed only against hypovolemia and its results. The infusion of macromolecular fluids, the restriction of sodium and water intake, together with the prescription of spironolactone have been successfully employed in those three cases.
超刺激现象出现在1例排卵后第10至11天，因其存在得以非常早期地诊断成功受精。血液凝固研究显示，高凝状态主要与血小板和凝血蛋白的活性过高有关。讨论了该综合征的发病机制。毛细血管通透性增加和血容量减少似乎是主要并发症的原因。遗憾的是，由于我们没有真正降低毛细血管通透性的方法，治疗只能针对血容量减少及其后果。在这3例患者中，输注大分子液体、限制钠和水的摄入以及使用螺内酯治疗均取得了成功。
