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[绵羊血浆芳基酯酶底物特异性的遗传控制]

[Genetic control of the substrate specificity of sheep plasma arylesterase].

作者信息

Glazko V I, Serov O L, Korochkin L I

出版信息

Genetika. 1975;11(2):79-86.

PMID:1232033
Abstract

By means of starch gel electrophoresis blood plasma esterases in sheep of different breeds were studied. It is shown that the esterase pattern is a poly-enzyme system consisting of at least three enzymes: arylesterase, carboxylesterase and choline esterase. Postnatal changes of esterase pattern in sheep blood plasma were also studied. Polymorphism on substrate specificities is described, which is expressed in the fact that different arylesterase variants have different affinity to alpha- and beta-isomers of carbone ethers of naphtol. The breeding test suggests that two allelic autosomal genes, reffered to as Es-1a and Es-1b, control the substrate specificity of arylesterase in sheep. The data are discussed in connection with Es-1a and Es-1b gene expression in heterozygous sheep, with the effect of (mosaic) dominance.

摘要

通过淀粉凝胶电泳法对不同品种绵羊的血浆酯酶进行了研究。结果表明,酯酶图谱是一个由至少三种酶组成的多酶系统:芳基酯酶、羧酸酯酶和胆碱酯酶。还研究了绵羊血浆中酯酶图谱的出生后变化。描述了底物特异性上的多态性,其表现为不同的芳基酯酶变体对萘酚碳酸酯的α-和β-异构体具有不同的亲和力。育种试验表明,两个常染色体等位基因,即Es-1a和Es-1b,控制绵羊芳基酯酶的底物特异性。结合杂合绵羊中Es-1a和Es-1b基因的表达以及(镶嵌)显性效应讨论了这些数据。

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1
[Genetic control of the substrate specificity of sheep plasma arylesterase].[绵羊血浆芳基酯酶底物特异性的遗传控制]
Genetika. 1975;11(2):79-86.
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