Cavazza A, Gelli M C, Agostini L, Sgarbi G, De Marco L, Gardini G
Unità Operativa di Anatomia Patologica, Ospedale S. Maria Nuova, Viale Risorgimento 80, I-42100 Reggio Emilia, Italia.
Pathologica. 2002 Aug;94(4):201-5. doi: 10.1007/s102420200032.
We describe a calcifying fibrous pseudotumour of pleura in a 46-year-old female, smoker. The patient presented with a well-delimited pleural mass, 3-cm across, located at the base of the right lung and attached to the lung with a short pedicle. Seven years after surgical excision of the mass, the patient is alive and well. Microscopically, the lesion was mostly composed of dense collagenous tissue, with sparse benign spindle cells, a rich inflammatory infiltrate and scattered calcifications, sometimes laminated. Immunohistochemically, spindle cells were positive for vimentin and negative for smooth muscle actin, desmin, S100 protein, CD34, CD99 and Bcl2. Calcifying fibrous pseudotumour is rare in the pleura. Pertinent data from the literature and problems in differential diagnosis are briefly discussed.
我们描述了一名46岁吸烟女性的胸膜钙化性纤维性假瘤。患者表现为一个边界清晰的胸膜肿块,直径3厘米,位于右肺底部,通过一个短蒂与肺相连。肿块手术切除7年后,患者健在。显微镜下,病变主要由致密的胶原组织组成,伴有稀疏的良性梭形细胞、丰富的炎性浸润和散在的钙化,有时呈层状。免疫组化显示,梭形细胞波形蛋白阳性,平滑肌肌动蛋白、结蛋白、S100蛋白、CD34、CD99和Bcl2阴性。胸膜钙化性纤维性假瘤罕见。简要讨论了文献中的相关数据及鉴别诊断问题。