Esbah Onur, Gürsoy Gül, Kirnap Nazli Gulsoy, Cetiner Hacer, Demirbaş Berrin, Acar Yasar, Bayram Murat
Department of Internal Medicine, Ministry of Health Ankara Education and Research Hospital, Ankara, Turkey.
J Res Med Sci. 2011 Oct;16(10):1273-9.
The association between C-reactive protein, homocysteine, uric acid levels and cardiovascular risk have been debated for decades. Resistin is a newly discovered adipocyte derived cytokine. Smoking besides its effect on atherosclerosis, is shown to alter adipocytokine levels. Bearing in mind, these complex relationship of resistin with smoking, C-reactive protein, homocysteine and uric acid, we planned to investigate the association of resistin and these cardiovascular risk factors in smoker and non-smoker subjects.
We conducted a cross-sectional randomized study including 52 smoking and 33 non-smoking men. After making comparisons of C-reactive protein, homocysteine, uric acid and resistin between the two groups, we classified the subjects according to their insulin resistance and body mass and made again the comparisons..
Resistin levels were higher in smokers than in non-smokers (p<0.001) and also in insulin resistant than in non-insulin resistant smokers (p<0.05). Resistin levels were indifferent in non-smokers as insulin resistance was concerned and in smoker or non-smokers as body mass index was concerned. As all subjects were grouped based on homeostasis model assesment index and body mass index, neither C-reactive protein nor homocysteine and uric acid levels differred.
We found that smoking may have influence on resistin levels and in smokers, insulin resistance is related to resistin levels, but in smoker and non-smokers body mass may not have any association with resistin. Resistin also may not have a role in C-reactive protein, homocysteine and uric acid levels both in smokers and non-smokers.
几十年来，C反应蛋白、同型半胱氨酸、尿酸水平与心血管风险之间的关联一直存在争议。抵抗素是一种新发现的脂肪细胞衍生细胞因子。吸烟除了对动脉粥样硬化有影响外，还会改变脂肪细胞因子水平。考虑到抵抗素与吸烟、C反应蛋白、同型半胱氨酸和尿酸之间的这些复杂关系，我们计划研究吸烟者和非吸烟者中抵抗素与这些心血管危险因素之间的关联。
我们进行了一项横断面随机研究，纳入了52名吸烟男性和33名非吸烟男性。在比较两组之间的C反应蛋白、同型半胱氨酸、尿酸和抵抗素之后，我们根据胰岛素抵抗和体重对受试者进行分类，并再次进行比较。
吸烟者的抵抗素水平高于非吸烟者（p<0.001），胰岛素抵抗的吸烟者的抵抗素水平也高于非胰岛素抵抗的吸烟者（p<0.05）。就胰岛素抵抗而言，非吸烟者的抵抗素水平无差异；就体重指数而言，吸烟者或非吸烟者的抵抗素水平也无差异。当根据稳态模型评估指数和体重指数对所有受试者进行分组时，C反应蛋白、同型半胱氨酸和尿酸水平均无差异。
我们发现吸烟可能会影响抵抗素水平，在吸烟者中，胰岛素抵抗与抵抗素水平有关，但在吸烟者和非吸烟者中，体重可能与抵抗素无任何关联。抵抗素在吸烟者和非吸烟者的C反应蛋白、同型半胱氨酸和尿酸水平中可能也不起作用。
