Jastrzebska M, Torbus-Lisiecka B, Honczarenko K, Foltynska A, Chełstowski K, Naruszewicz M
Clinical Biochemistry and Laboratory Diagnostics, Regional Center for Atherosclerosis Research, Pomeranian Academy of Medicine, Al. Powstaców Wlkp. 72, PL-70-111 Szczecin, Poland.
Nutr Metab Cardiovasc Dis. 2002 Jun;12(3):132-40.
Von Willebrand factor (vWF) and fibrinogen (Fb) have recently emerged as plausible familial determinants of atherothrombosis. We investigated whether the vWF and Fb levels in patients with ischemic cerebrovascular stroke (ICS) correlate with those in their children.
The study group consisted of 28 families (56 parents and 34 children) with one parent who had suffered an ICS at least three months before the study. All of the ICS patients had hyperlipoproteinemia and most arterial hypertension. The control group consisted of 15 families (30 parents and 20 children). The age of the parents and children did not exceed 55 and 16 years. The ICS parents had significantly higher vWF, Fb and protein C (PC) levels than the controls (vWF--fathers: 121.0 +/- 42.5% vs 79.2 +/- 23.4%; vWF--mothers: 110.7 +/- 40.1% vs 82.4 +/- 20.9%; Fb--fathers: 4.12 +/- 0.74 g/L vs 3.01 +/- 0.54 g/L; Fb--mothers: 3.64 +/- 0.84 gL vs 2.98 +/- 0.35 g/L; PC--fathers: 116.0 +/- 12.3% vs 105.6 +/- 13.7%; PC--mothers: 114.4 +/- 15.8% vs 105.0 +/- 12.2%). The children of the ICS parents had significantly higher PC and body mass index (BMI) values than the controls (PC: 102.6 +/- 13.7% vs 92.7 +/- 10.7%; BMI: 20.6 +/- 3.8 vs 17.8 +/- 3.5 Kg/m2), as well as an atherogenic lipid profile, higher blood pressure (BP) and a tendency toward higher vWF levels. Correlations between the ICS parents and their children were found for vWF, factor VIIc, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and BP, which were closer in the case of fathers.
Regardless of gender, the parents with a history of ICS had a procoagulant state, with high levels of vWF, Fb and PC. In terms of inheritance, the most adverse risk factor profile was found in the children of ICS fathers.
血管性血友病因子（vWF）和纤维蛋白原（Fb）最近已成为动脉粥样硬化血栓形成可能的家族性决定因素。我们研究了缺血性脑血管病（ICS）患者的vWF和Fb水平与其子女的水平是否相关。
研究组由28个家庭（56名父母和34名子女）组成，其中一名父母在研究前至少三个月曾患过ICS。所有ICS患者均患有高脂蛋白血症，且大多患有动脉高血压。对照组由15个家庭（30名父母和20名子女）组成。父母和子女的年龄分别不超过55岁和16岁。ICS患者父母的vWF、Fb和蛋白C（PC）水平显著高于对照组（vWF——父亲：121.0±42.5% 对79.2±23.4%；vWF——母亲：110.7±40.1% 对82.4±20.9%；Fb——父亲：4.12±0.74 g/L对3.01±0.54 g/L；Fb——母亲：3.64±0.84 g/L对2.98±0.35 g/L；PC——父亲：116.0±12.3% 对105.6±13.7%；PC——母亲：114.4±15.8% 对105.0±12.2%）。ICS患者父母的子女的PC和体重指数（BMI）值显著高于对照组（PC：102.6±13.7% 对92.7±10.7%；BMI：20.6±3.8对17.8±3.5 Kg/m2），同时具有致动脉粥样硬化的血脂谱、更高的血压（BP）以及vWF水平升高的趋势。发现ICS患者父母与其子女在vWF、凝血因子VIIc、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和BP方面存在相关性，在父亲方面相关性更强。
无论性别如何，有ICS病史的父母均处于促凝状态，vWF、Fb和PC水平较高。在遗传方面，ICS父亲的子女具有最不利的危险因素谱。
