Arslan Yıldız, Yoldaş Tahir Kurtuluş, Zorlu Yaşar
Neurology Clinic, İzmir Tepecik Education and Research Hospital, Yenişehir Mah, 35120, Konak, Izmir, Turkey,
Transl Stroke Res. 2013 Oct;4(5):484-7. doi: 10.1007/s12975-013-0259-0. Epub 2013 Apr 25.
The von Willebrand factor (vWF) levels increase in acute-phase ischemic stroke because of endothelial dysfunction and thrombus formation and may reduce acetylsalicylic acid (ASA) efficiency in hemostatic cascade. The aim of the study is to investigate the relationship between vWF levels and ASA resistance in ischemic stroke patients. Fifty acute ischemic stroke patients (mean age 66.3±13 years, 34 males) were given 300 mg/day aspirin for at least 10 days, and 25 healthy volunteers as a control group were compared using platelet function analyzer-100 test. All risk factors were investigated for a correlation to ASA resistance. ASA resistance was apparent in 32% of the study group and in 20% of the control group (p=0.140). vWF levels were elevated in only ASA nonresponders and the ischemic stroke group that showed a statistically significant association with aspirin resistance (p≤0.05). vWF levels increase in ASA nonresponders and ischemic stroke group in acute phase. High vWF levels may relate to ASA resistance and recurrent strokes.
由于内皮功能障碍和血栓形成，急性缺血性卒中患者的血管性血友病因子（vWF）水平会升高，这可能会降低乙酰水杨酸（ASA）在止血级联反应中的疗效。本研究旨在探讨缺血性卒中患者vWF水平与ASA抵抗之间的关系。50例急性缺血性卒中患者（平均年龄66.3±13岁，男性34例）接受300mg/天阿司匹林治疗至少10天，并使用血小板功能分析仪-100检测，与25名健康志愿者作为对照组进行比较。研究了所有危险因素与ASA抵抗的相关性。研究组中32%出现ASA抵抗，对照组中20%出现ASA抵抗（p=0.140）。仅在ASA无反应者和缺血性卒中组中vWF水平升高，且与阿司匹林抵抗存在统计学显著相关性（p≤0.05）。急性期ASA无反应者和缺血性卒中组的vWF水平升高。高vWF水平可能与ASA抵抗和复发性卒中有关。
