Röllinghoff M, Wagner H
J Immunol. 1975 Apr;114(4):1329-32.
The primary immune response against sheep red blood cells in T cell-deficient spleen cell cultures from nude mice was tested in the absence and presence of allogeneic spleen cells. The allogeneic spleen cells differed either in regard to the major histocompatibility complex (H-2) or only with respect to the M-locus. Surprisingly the M-locus different spleen cells were almost as efficient in enhancing the anti-sheep red blood cell response in nude cultures as were the cells differing on the complete H-2 complex. Evidence is presented that AKR anti-theta serum sensitive T cells are responsible for the M-locus-dependent effect edscribed. This effect is shown to be mediated by a factor released from actived T cells stimulated in M-locus different mixed lymphocyte cultures. Since almost identical parameters have been observed in both the M-locus-dependent situation as in the "classical" allogeneic situation we concluded that an allogeneic effect can be induced by T cells responding to a complete set of the major histocompatibility complex (H-2) as well as to lymphocyte-activating determinants (M-locus) alone.
在无胸腺裸鼠的T细胞缺陷脾细胞培养物中，检测了在有无同种异体脾细胞存在的情况下，针对绵羊红细胞的初次免疫反应。同种异体脾细胞在主要组织相容性复合体（H-2）方面存在差异，或者仅在M位点方面存在差异。令人惊讶的是，在裸鼠培养物中，M位点不同的脾细胞在增强抗绵羊红细胞反应方面几乎与在完整H-2复合体上存在差异的细胞一样有效。有证据表明，AKR抗θ血清敏感的T细胞对所述的M位点依赖性效应负责。这种效应被证明是由在M位点不同的混合淋巴细胞培养物中被激活的T细胞释放的一种因子介导的。由于在M位点依赖性情况和“经典”同种异体情况中观察到几乎相同的参数，我们得出结论，同种异体效应可由对主要组织相容性复合体（H-2）全套以及仅对淋巴细胞激活决定簇（M位点）作出反应的T细胞诱导产生。
