Matossian-Rogers A
Immunology. 1979 Aug;37(4):801-6.
During the immune response to H-2 and Mls alloantigens, murine lymphocytes showed altered sensitivity to polyclonal mitogens. The reactivity to the T-cell mitogen PHA followed a similar pattern in both H-2 and Mls-immunized mice while the reactivity to the B-cell mitogen LPS was contrasting in the two groups. In the former group, the response exceeded control levels by the seventh day after immunization and then gradually dropped below control levels; the response of Mls-immunized lymphocytes dropped below control levels soon after immunization and remained so for the period of study. Nylon wool column-purified Mls-immunized B cells also showed a suppressed reactivity to LPS, while the T-enriched populations from Mls-immune mice when added to normal B cells lowered their LPS reactivity. Soluble factors derived from clutures of Mls-immune lymphocytes had a suppressive effect on normal B cells.
在对H-2和Mls同种异体抗原的免疫反应过程中,小鼠淋巴细胞对多克隆有丝分裂原的敏感性发生了改变。在H-2免疫小鼠和Mls免疫小鼠中,对T细胞有丝分裂原PHA的反应遵循相似模式,而对B细胞有丝分裂原LPS的反应在两组中形成对比。在前一组中,免疫后第7天反应超过对照水平,然后逐渐降至对照水平以下;Mls免疫淋巴细胞的反应在免疫后不久就降至对照水平以下,并在研究期间一直保持。经尼龙毛柱纯化的Mls免疫B细胞对LPS的反应性也受到抑制,而来自Mls免疫小鼠的富含T细胞的群体加入正常B细胞后会降低其对LPS的反应性。来自Mls免疫淋巴细胞培养物的可溶性因子对正常B细胞有抑制作用。