T细胞对自身改变的应答中可溶性辅助分子的主要组织相容性复合体限制
Major histocompatibility complex restriction of soluble helper molecules in T cell responses to altered self.
作者信息
Plate J M
出版信息
J Exp Med. 1981 May 1;153(5):1102-12. doi: 10.1084/jem.153.5.1102.
Abstract
Evidence for major histocompatibility complex (MHC) restriction of soluble helper effects was observed in the generation of syngeneic killer T cells to trinitrophenyl-altered self. Ia-bearing T cells obscure the observation of such interactions, thus, must be removed to detect MHC restriction of nonspecific soluble helper factor supernates (HFS). Genetic mapping studies demonstrated that the strain producing HFS must be compatible in the H-21A region with the strain utilizing the helper molecules for optimal helper signals to be delivered.
摘要
在同基因杀伤性T细胞针对三硝基苯基改变的自身抗原的产生过程中，观察到了可溶性辅助效应的主要组织相容性复合体（MHC）限制的证据。携带Ia的T细胞会掩盖此类相互作用的观察结果，因此，必须去除这些细胞以检测非特异性可溶性辅助因子上清液（HFS）的MHC限制。基因定位研究表明，产生HFS的品系在H-21A区域必须与利用辅助分子的品系相容，以便传递最佳的辅助信号。
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