Nakamura M, Kuroiwa A, Nakagaki O, Tomoike H, Nose Y
Jpn Heart J. 1975 Mar;16(2):156-61. doi: 10.1536/ihj.16.156.
Twenty spontaneously hypertensive rats (SHR) and 20 control rats were used for measurements of Rb86 uptake of various organs. Hemodynamic measurements and the heart weight to body weight ratio showed a significant and sustained hypertension and increased heart rate in SHR; Ratio of Rb86 uptake in the kidney, brain, liver, adrenal gland, pancreas, and spleen to that in RV was smaller in SHR than that in the control rats. The ratio of Rb86 uptake of inner layer to outer layer of LV, which represents distribution of blood flow to the endocardial layer and epicardial layer, was not different between SHR and the control rats. The fraction of regional flow in the outer and inner cortex, juxtamedulla, and medulla of the kidney was not different between SHR and the control. The present preliminary study may suggest that myocardial blood flow in SHR is greater than that in the control rats. The relationship between cardiac hypertrophy and myocardial flow was discussed.
选用20只自发性高血压大鼠（SHR）和20只对照大鼠，用于测量各器官的86Rb摄取量。血流动力学测量以及心脏重量与体重之比显示，SHR存在显著且持续的高血压以及心率增加；SHR肾脏、脑、肝脏、肾上腺、胰腺和脾脏的86Rb摄取量与右心室的比值低于对照大鼠。左心室内层与外层86Rb摄取量的比值代表心内膜层和心外膜层的血流分布，SHR与对照大鼠之间无差异。SHR与对照大鼠肾脏外皮质、内皮质、近髓质和髓质的局部血流分数无差异。本初步研究可能提示，SHR的心肌血流量大于对照大鼠。文中讨论了心脏肥大与心肌血流之间的关系。
