Datsis S A
Exp Pathol (Jena). 1975;10(1-2):1-27. doi: 10.1016/s0014-4908(75)80002-0.
Scanning electron microscopic investigations on rats subjected to DL-3,a-dimethyltyrosine methylester HCl treatment, indicated that the drug in reference induces renal lesions substantiated by proximal tubular epithelial cell regression and eventual exfoliation, coupled by formation of 3,a-dimethyltyrosine calculi both in the upper and lower segments of the urinary tract. The development of calculi was found to be preceded by a moderate to massive precipitation of a fibrin-like substance intermixed with blood cells, and with an occasionally concomitant deposition of exfoliated cells of epithelial origin, to be succeeded by precipitation of crystals.
对接受DL-3、α-二甲基酪氨酸甲酯盐酸盐治疗的大鼠进行扫描电子显微镜研究表明，该参比药物会诱发肾脏损伤，表现为近端肾小管上皮细胞退化并最终脱落，同时在尿路的上段和下段形成α-二甲基酪氨酸结石。研究发现，结石形成之前会有中等程度到大量的纤维蛋白样物质沉淀，这些物质与血细胞混合，偶尔还伴有上皮来源的脱落细胞沉积，随后是晶体沉淀。
