Wender M, Adamczewska Z
Exp Pathol (Jena). 1975;11(5-6):233-8. doi: 10.1016/s0014-4908(75)80081-0.
From the analysis of the fatty acid spectrum of the individual lipid fractions of the cerebral white matter in cyanide induced encephalopathy would appear that essentially the phosphatidyl ethanolamine and plasmalogen fractions showed appreciable deviations from the control spectra. The observed changes in the cholesteryl ester composition did not correlate with the macrophage reaction, which is known to appear as late as 14 days after HCN intoxication when morphological signs of demyelination become apparent. Neither was there a correlation between the alterations of the phosphatide fatty acid composition and that of cholesteryl esters. It thus would appear that esterification of cholesterol in the myelin of rats occurring during early stages following cyanide intoxication constitutes one of the primary factors injuring the myelin sheath. The same conclusion seems to be applicable to the changes in fatty acid composition of the white matter phospholipids.
通过对氰化物诱导性脑病中脑白质各个脂质组分的脂肪酸谱分析，似乎磷脂酰乙醇胺和缩醛磷脂组分与对照谱相比有明显偏差。观察到的胆固醇酯组成变化与巨噬细胞反应无关，已知巨噬细胞反应在HCN中毒后14天才出现，此时脱髓鞘的形态学迹象变得明显。磷脂脂肪酸组成的变化与胆固醇酯的变化之间也没有相关性。因此，似乎在氰化物中毒后的早期阶段，大鼠髓鞘中胆固醇的酯化是损伤髓鞘的主要因素之一。同样的结论似乎也适用于白质磷脂脂肪酸组成的变化。
