烷基硝基脲衍生物中毒对脑髓磷脂的影响。

The effect of intoxication with alkylnitrosourea derivatives on cerebral myelin.

作者信息

Wender M, Adamczewska-Goncerzewicz Z, Mularek O, Zgorzalewicz B

出版信息

Adv Exp Med Biol. 1978;100:487-98. doi: 10.1007/978-1-4684-2514-7_35.

Abstract

Adult BD IX rats were injected with methylnitrosourea and pregnant mice on the 15th day of gestation with a single intravenous dose of ethylnitrosourea and pregnant mice on the 15th day of gestation with a single intravenous dose of ethylnitrosourea. The cerebral myelin fraction of adult BD IX rats and of the mice offsprings was studied. It was found that a part of the rats intoxicated with methylnitrosourea developed spongious changes in the cerebral and cerebellar white matter. The myelin fraction of intoxicated rats also showed severe losses of sphingomyelin with a steady increase in the cholesterol ester content. The myelin fraction from mice intoxicated during the foetal development appeared deficient with respect to galactolipids and plasmalogen. It is concluded that, besides the carcinogenic effect, alkylnitrosourea derivatives effectively disturb the lipid metabolism of membrane structures of the central nervous system.

摘要

成年BD IX大鼠注射甲基亚硝基脲，妊娠第15天的怀孕小鼠静脉注射单剂量的乙基亚硝基脲。研究了成年BD IX大鼠及其后代小鼠的脑髓磷脂部分。发现部分用甲基亚硝基脲中毒的大鼠在大脑和小脑白质出现海绵状变化。中毒大鼠的髓磷脂部分还显示鞘磷脂严重损失，胆固醇酯含量稳步增加。在胎儿发育期间中毒的小鼠的髓磷脂部分在半乳糖脂和缩醛磷脂方面似乎不足。得出的结论是，除致癌作用外，烷基亚硝基脲衍生物还能有效干扰中枢神经系统膜结构的脂质代谢。