Harada T
Gastroenterol Jpn. 1975;10(2):174-8. doi: 10.1007/BF02774847.
Biliary bile acid have been analyzed in patients with various hepato-biliary diseases by thin-layer chromatography, and divided into 4 types of glycine- and taurine-conjugates. The composition of biliary bile acid was different according to the hepatic impairement, and the ratio of glycine-conjugate to taurine-conjugate was decreased in chronic liver diseases. The G/T ratio was 1.49 +/- 0.36 in the control group, but was 0.96 +/- 0.18 in severe liver cirrhosis, and 1.38 +/- 0.44 in chronic active hepatitis. In acute hepatitis, the G/T ratio was low on the initial stage of the diseases, and returned to a normal range upon recovery. There was also a dicrease in the ratio of dihydroxycholic to cholic acid of biliary bile acid in patients with chronic liver diseases. In conclusion, the measurement of bile acid in bile has a diagnostic value for chronic hepatic impairement.
已通过薄层色谱法对各种肝胆疾病患者的胆汁胆汁酸进行了分析，并将其分为4种甘氨酸和牛磺酸结合物类型。胆汁胆汁酸的组成因肝脏损害而异，慢性肝病中甘氨酸结合物与牛磺酸结合物的比例降低。对照组的G/T比值为1.49±0.36，但在严重肝硬化中为0.96±0.18，在慢性活动性肝炎中为1.38±0.44。在急性肝炎中，疾病初期G/T比值较低，恢复后恢复到正常范围。慢性肝病患者胆汁中胆汁酸的二羟基胆酸与胆酸的比例也降低。总之，胆汁中胆汁酸的测定对慢性肝损害具有诊断价值。
