Nosaka Y, Yamanishi Y, Hirayama C
Gastroenterol Jpn. 1985 Aug;20(4):338-43. doi: 10.1007/BF02774744.
Following overnight fasting, biliary levels of squalene, bile salts, cholesterol and phospholipid were estimated using human bile obtained with a duodenal double lumen catheter after administration of caerulein. While the squalene level in B-bile was 6.86 microM in the control group, it fell significantly in patients with parenchymal liver diseases, especially liver cirrhosis. There was no significant change in the level in patients with cholelithiasis. Biliary squalene concentration showed a significant correlation with concentrations of bile salts, cholesterol and phospholipid. These results substantiate the possibility that the biliary squalene level reflects sterol metabolism in the liver.
经过一夜禁食后，在注射蛙皮素后，使用十二指肠双腔导管获取的人胆汁来测定角鲨烯、胆盐、胆固醇和磷脂的胆汁水平。对照组中B胆汁的角鲨烯水平为6.86微摩尔，而在实质性肝病患者，尤其是肝硬化患者中，该水平显著下降。胆结石患者的该水平无显著变化。胆汁角鲨烯浓度与胆盐、胆固醇和磷脂浓度呈显著相关性。这些结果证实了胆汁角鲨烯水平反映肝脏中甾醇代谢的可能性。
