Votocková J, Brettschneider I, Balík J, Cejková J, Kloucek F
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1975;193(3):217-28. doi: 10.1007/BF00440980.
The essence of the process in which the corneal tissue disappears in atrophy of the eye has not yet been studied. The authors of this investigation studied the changes in cornea as they developed after a gross perforating injury to the eye in rabbit. They found that the diameter of the cornea had grown smaller by 2 mm and its radius by 0.5 mm. The tensile strength of the cornea had decreased and hydration increased. Histologically there were but little changes and histochemically a decreased amount of acid mucopolysaccharides was ascertained in the corneal stroma. Incorporation of radioactive sulphate (Na2-35SO4) in vivo disclosed decreased biosynthesis of glycosaminoglycans. Clinically, even though the eye ball atrophied, complete atrophy with flattening and complete diminution, as in the human eye, never developed. The question arises whether the six-months period was sufficient for rabbit cornea to develop clinically similar atrophy as in human cornea or whether the clinical features are principally different in the two species. Foci of ossification, as found in atrophic eye balls, which are known to develop after a long time, would be evidence of the second alternative.
眼球萎缩时角膜组织消失这一过程的本质尚未得到研究。本研究的作者研究了兔眼遭受严重穿孔伤后角膜的变化情况。他们发现角膜直径缩小了2毫米，半径缩小了0.5毫米。角膜的抗张强度降低，含水量增加。组织学上变化不大，组织化学检测发现角膜基质中酸性粘多糖的含量减少。体内放射性硫酸盐（Na2-35SO4）的掺入表明糖胺聚糖的生物合成减少。临床上，尽管眼球萎缩，但从未出现像人眼那样完全萎缩、扁平且完全缩小的情况。问题在于，六个月的时间对于兔角膜发展出与人角膜临床上相似的萎缩是否足够，或者这两个物种的临床特征在本质上是否不同。在萎缩眼球中发现的骨化灶，已知是在很长时间后才会出现，这将是第二种情况的证据。
