Leonardo S, de Levinton A M, Miranda C, De Tombolesi A R, Buys M C
Acta Physiol Lat Am. 1975;25(4):358-64.
Carbon monoxide injected subcutaneously in mice produces a profound intoxication during a six hour-period. From 2 to 4 hr after the start of carbon monoxide (CO)-hypoxemia large amounts of erythropoietin (ESF) are released in the plasma. Renal extracts obtained at the same time showed higher specific activity than that found in the plasma extracts. No activity was recovered from liver and spleen extracts. Removal of the kidney abolishes totally the production of ESF.
皮下注射一氧化碳的小鼠在6小时内会出现严重中毒。在一氧化碳（CO）性低氧血症开始后的2至4小时内，大量促红细胞生成素（ESF）释放入血浆。同时获得的肾提取物显示出比血浆提取物更高的比活性。肝脏和脾脏提取物未检测到活性。摘除肾脏会完全消除ESF的产生。
