Guidi E E, Scaro J L, Carrera M A
Rev Esp Fisiol. 1976 Jun;32(2):149-52.
The effects of the beta-adrenergic blocking agent (propranolol) on erythropoietin production in carbon monoxide intoxicated mice were studied. The raise in plasma erythropoietin after a 4 hour intoxication with carbon monoxide was 47% less in the propranolol treated group. A decrease of 65% in the endogenous erythropoietic response after 75 minutes of carbon monoxide intoxication was found in policithemic treated mice, as against the untreated ones. The tissue oxygen tension was reduced in the propranolol treated group. No changes was found in the hemoglobin oxygen affinity.
研究了β-肾上腺素能阻滞剂（普萘洛尔）对一氧化碳中毒小鼠促红细胞生成素产生的影响。在普萘洛尔治疗组中，一氧化碳中毒4小时后血浆促红细胞生成素的升高比未治疗组少47%。与未治疗小鼠相比，在多血症治疗的小鼠中，一氧化碳中毒75分钟后内源性促红细胞生成反应降低了65%。普萘洛尔治疗组的组织氧张力降低。血红蛋白氧亲和力未发现变化。
