• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

正常、智力缺陷及衰老人类大脑中突触和神经元的密度

The density of synapses and neurons in normal, mentally defective ageing human brains.

作者信息

Cragg B G

出版信息

Brain. 1975 Mar;98(1):81-90. doi: 10.1093/brain/98.1.81.

DOI:10.1093/brain/98.1.81
PMID:123474
Abstract

The densities of synapses and neurons were measured in 7 neurosurgical specimens of cerebral cortex, regarded as normal controls. The average result was 6 times 10-11 synapses/cm3, 15-6 times 10-6 neurons/cm3, and 38,000 synapses per neuron. Specimens of frontal and temporal cortex from 7 ageing brains (68 to 89 years) gave closely similar counts of neurons and synapses. Seven specimens from 3 severely retarded brains gave similar counts of neurons and slightly higher counts of synapses. A deficit of synaptic development is thus not a necessarre discussed.

摘要

在7个被视为正常对照的大脑皮质神经外科标本中测量了突触和神经元的密度。平均结果为6×10⁻¹¹个突触/立方厘米、15 - 6×10⁻⁶个神经元/立方厘米以及每个神经元有38000个突触。来自7个老年大脑(68至89岁)的额叶和颞叶皮质标本给出了与之非常相似的神经元和突触计数。来自3个严重智力迟钝大脑的7个标本给出了相似的神经元计数以及稍高的突触计数。因此,突触发育不足并非必然。 (注:原文中necessarre拼写错误,可能是necessary,这里按正确理解翻译)

相似文献

1
The density of synapses and neurons in normal, mentally defective ageing human brains.正常、智力缺陷及衰老人类大脑中突触和神经元的密度
Brain. 1975 Mar;98(1):81-90. doi: 10.1093/brain/98.1.81.
2
A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease.阿尔茨海默病患者额叶和颞叶皮质神经元及突触含量的定量形态学分析。
J Neurol Sci. 1987 Apr;78(2):151-64. doi: 10.1016/0022-510x(87)90057-8.
3
Axonic and synaptic changes in a case of psychomotor retardation: an electron microscopic study.一例精神运动迟缓患者的轴突和突触变化:一项电子显微镜研究。
J Neuropathol Exp Neurol. 1967 Apr;26(2):179-99. doi: 10.1097/00005072-196704000-00001.
4
Williams syndrome: a relationship between genetics, brain morphology and behaviour.威廉姆斯综合征:遗传学、脑形态与行为之间的关系。
J Intellect Disabil Res. 2012 Sep;56(9):879-94. doi: 10.1111/j.1365-2788.2011.01490.x. Epub 2011 Nov 2.
5
Synaptic density in human frontal cortex - developmental changes and effects of aging.人类额叶皮质中的突触密度——发育变化及衰老的影响
Brain Res. 1979 Mar 16;163(2):195-205. doi: 10.1016/0006-8993(79)90349-4.
6
"Cryptic tubers" as a cause of focal epilepsy.“隐匿性结节”作为局灶性癫痫的一个病因
J Neurol Neurosurg Psychiatry. 1971 Feb;34(1):104-5. doi: 10.1136/jnnp.34.1.104-b.
7
EM study of the numbers of cortical synapses in the brains of ageing people and people with Alzheimer-type dementia.对老年人和患有阿尔茨海默型痴呆症患者大脑中皮质突触数量的电子显微镜研究。
Acta Neuropathol. 1983;62(1-2):127-33. doi: 10.1007/BF00684929.
8
[Morphological and quantatitive capillary changes in aging human brain].[衰老人类大脑中毛细血管的形态学和定量变化]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Apr;26(2):104-7.
9
Cell counts in cerebral cortex of an autistic patient.一名自闭症患者大脑皮层中的细胞计数。
J Autism Dev Disord. 1985 Sep;15(3):245-55. doi: 10.1007/BF01531496.
10
Effect of brain lesions on the rapidity of arm movement.脑部病变对手臂运动速度的影响。
Neurology. 1967 Nov;17(11):1113-20. doi: 10.1212/wnl.17.11.1113.

引用本文的文献

1
MLKL overexpression leads to Ca and metabolic dyshomeostasis in a neuronal cell model.MLKL 过表达导致神经元细胞模型中钙和代谢稳态失调。
Cell Calcium. 2024 May;119:102854. doi: 10.1016/j.ceca.2024.102854. Epub 2024 Feb 6.
2
Formulating treatment of major psychiatric disorders: algorithm targets the dominantly affected brain cell-types.制定主要精神疾病的治疗方案:算法针对主要受影响的脑细胞类型。
Discov Ment Health. 2023 Jan 5;3(1):3. doi: 10.1007/s44192-022-00029-8.
3
Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease.
阿尔茨海默病中小胶质细胞和星形胶质细胞清除含有 Tau 寡聚物的突触。
JAMA Neurol. 2023 Nov 1;80(11):1209-1221. doi: 10.1001/jamaneurol.2023.3530.
4
The influence of age and sex on the absolute cell numbers of the human brain cerebral cortex.年龄和性别对人脑大脑皮层绝对细胞数量的影响。
Cereb Cortex. 2023 Jun 20;33(13):8654-8666. doi: 10.1093/cercor/bhad148.
5
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.唐氏综合征合并阿尔茨海默病患者及 Dp16 小鼠唐氏综合征模型中突触蛋白和 SNARE 复合物减少:APP 基因剂量的影响。
Alzheimers Dement. 2023 May;19(5):2095-2116. doi: 10.1002/alz.12835. Epub 2022 Nov 12.
6
Fast Simulation of a Multi-Area Spiking Network Model of Macaque Cortex on an MPI-GPU Cluster.猕猴皮层多区域脉冲神经网络模型在MPI-GPU集群上的快速模拟
Front Neuroinform. 2022 Jul 4;16:883333. doi: 10.3389/fninf.2022.883333. eCollection 2022.
7
Neurite density and arborization is associated with reading skill and phonological processing in children.神经突密度和分支与儿童的阅读技能和语音处理有关。
Neuroimage. 2021 Nov 1;241:118426. doi: 10.1016/j.neuroimage.2021.118426. Epub 2021 Jul 22.
8
Comparative neuropathology in aging primates: A perspective.衰老灵长类动物的比较神经病理学:一个视角。
Am J Primatol. 2021 Nov;83(11):e23299. doi: 10.1002/ajp.23299. Epub 2021 Jul 13.
9
The role of cofilin in age-related neuroinflammation.丝切蛋白在与年龄相关的神经炎症中的作用。
Neural Regen Res. 2020 Aug;15(8):1451-1459. doi: 10.4103/1673-5374.274330.
10
Factors Affecting Ultrastructural Quality in the Prefrontal Cortex of the Postmortem Human Brain.影响人脑前额叶皮质超微结构质量的因素。
J Histochem Cytochem. 2019 Mar;67(3):185-202. doi: 10.1369/0022155418819481. Epub 2018 Dec 18.