Lemon H M
Cancer Res. 1975 May;35(5):1341-53.
The concentration of estrogenic, androgenic, progestational, and adrenocortical steroid hormones in body fluids of mature intact Sprague-Dawley female rats was increased by s.c. implantation of 5 to 7 mg NaCl pellets containing 1 to 20% steroid 48 hr before administration p.o. of either 7,12-dimethylbenz(a) anthracene or procarbazine. The incidence of rats developing one or more mammary carcinomas in each treated group was compared to that ovserved in simultaneously treated groups receiving only the carcinogen, steroid, or no treatment whatsoever, with weekly observation of all rats until palpably growing tumors were biopsied and proven carcinomatous or until death occurred from other causes determined by autopsy. A total of 105 untreated or steroid-implanted rats followed to death (234 to 256 days median observation) developed no breast carcinomas. Rats fed either of the carcinogens developed initial evidence of breast carcinoma, after 136 to 156 days median observation, in 51 to 57% of 318 total treated rats. Nonbreast carcinomas and sarcomas developed in 5 to 10% of the carcinogen-treated rats.
在经口给予7,12-二甲基苯并(a)蒽或丙卡巴肼前48小时，通过皮下植入含1%至20%类固醇的5至7毫克氯化钠丸剂，可使成熟未切除卵巢的Sprague-Dawley雌性大鼠体液中的雌激素、雄激素、孕激素和肾上腺皮质类固醇激素浓度升高。将每个治疗组中发生一个或多个乳腺癌的大鼠发生率与同时接受仅致癌物、类固醇或未接受任何治疗的治疗组中观察到的发生率进行比较，每周观察所有大鼠，直至可触及生长的肿瘤进行活检并证实为癌性，或直至因尸检确定的其他原因死亡。总共105只未治疗或植入类固醇的大鼠随访至死亡（中位观察期为234至256天），未发生乳腺癌。在318只接受治疗的大鼠中，经口给予任何一种致癌物的大鼠在中位观察期136至156天后，有51%至57%出现乳腺癌的初步迹象。5%至10%接受致癌物治疗的大鼠发生了非乳腺癌和肉瘤。
