二甲基亚硝胺对中国仓鼠（黑线仓鼠）的致癌作用。
The carcinogenic effect of dimethylnitrosamine on the Chinese hamster (Cricetulus griseus).
作者信息
Reznik G
出版信息
Cancer Lett. 1975 Sep;1(1):25-8. doi: 10.1016/s0304-3835(75)94759-x.
Three groups of Chinese hamsters (20 males, 20 females/group) received weekly subcutaneous injections for life of dimethylnitrosamine (DMN) at dose levels 0.20, 0.10 and 0.05 of the LD50. Eighty-two to 100% of the animals developed tumors of vascular origin. The neoplasms were primarily hepatic hemangioendotheliomas and their incidence was unrelated to dose or sex. Although animals in the low dose group received a total dose which was one-third that of the highest dose group, their survival times were only slightly longer.
三组中国仓鼠（每组20只雄性、20只雌性）终生每周接受皮下注射二甲基亚硝胺（DMN），剂量分别为LD50的0.20、0.10和0.05。82%至100%的动物发生了血管源性肿瘤。肿瘤主要为肝血管内皮瘤，其发生率与剂量或性别无关。虽然低剂量组动物接受的总剂量仅为高剂量组的三分之一，但其存活时间仅略长一些。
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