Rose R M, Hurst M W
J Human Stress. 1975 Mar;1(1):22-36. doi: 10.1080/0097840X.1975.9940401.
Plasma cortisol and growth hormone (HGH) responses to venous catheterization were studied in 29 volunteer subjects. Repeat characterizations were performed in 18 individuals. Mean plasma cortisol levels were significantly elevated during the first hour of the initial catheterization experience. Morning and afternoon levels of cortisol were not distinguishable during the first catheterization, but PM levels were significantly lower than AM levels during the second catheterization experience. Growth hormone responses were much more variable than cortisol and were distributed logarithmically. Growth hormone responses tended to parallel cortisol responses during the first catheterization experience. Individuals who listed more symptoms in response to venipuncture and catheterization after finishing their first catheterization had significantly higher cortisol and growth hormone levels during this experience. These data suggest a definite endocrine adaptation to catheterization by the second or third hour of the experience.
对29名志愿者进行了研究，以观察血浆皮质醇和生长激素（HGH）对静脉插管的反应。对18名个体进行了重复测定。在首次插管过程的第一个小时内，平均血浆皮质醇水平显著升高。在首次插管期间，上午和下午的皮质醇水平没有差异，但在第二次插管过程中，下午的水平显著低于上午的水平。生长激素的反应比皮质醇的反应更具变异性，且呈对数分布。在首次插管过程中，生长激素的反应倾向于与皮质醇的反应平行。在完成首次插管后，对静脉穿刺和插管列出更多症状的个体在此过程中皮质醇和生长激素水平显著更高。这些数据表明，在经历的第二个或第三个小时，身体对插管有明确的内分泌适应。
